Immunopipe: a comprehensive and flexible scRNA-seq and scTCR-seq data analysis pipeline.

ABSTRACT: Single-cell sequencing technologies provide us with information at the level of individual cells. Combining single-cell RNA-seq and single-cell TCR-seq profiling enables the exploration of cell heterogeneity and T-cell receptor repertoires simultaneously. Integrating both types of data can play a crucial role in enhancing our understanding of T-cell-mediated immunity and, in turn, facilitate the advancement of immunotherapy. Here, we present immunopipe, a comprehensive and flexible pipeline to perform integrated analysis of scRNA-seq and scTCR-seq data. In addition to the command line tool, we provide a user-friendly web interface for pipeline configuration and execution monitoring, benefiting researchers without extensive programming experience. With its comprehensive functionality and ea

SUBMITTER: Wang P 

PROVIDER: S-EPMC12086537 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature