A path integral approach for allele frequency dynamics under polygenic selection.

ABSTRACT: Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotypes. One promising avenue to resolve the genetic basis of complex traits is through evolve-and-resequence (E&R) experiments, in which laboratory populations are exposed to some selective pressure and trait-contributing loci are identified by extreme frequency changes over the course of the experiment. However, small laboratory populations will experience substantial random genetic drift, and it is difficult to determine whether selection played a role in a given allele frequency change (AFC). Predicting AFCs under drift and selection, even for alleles contributing to simple, monogenic traits, has remained a challenging problem. Recently, there have

SUBMITTER: Anderson NW 

PROVIDER: S-EPMC12086674 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature