Acute kidney injury with hypernatremia and major adverse kidney events.

ABSTRACT:

Introduction

Consequences of hypernatremia in akute kidney injury (AKI-hyperNa) is poorly understood. We analyzed the risk of major adverse kidney events (MAKE) in comparison with AKI and normal serum sodium (AKI-normalNa). Such data could help in understanding this complex interaction.

Methods

In this retrospective cohort we compared the AKI-hyperNa with the AKI-normalNa regarding the risk of MAKE, which include death, new dialysis requirement, and worsening kidney function (≥25% decrease in estimated glomerular filtration rate), at 10 (MAKE10) and at 30-90 days (MAKE30-90) using multivariate logistic regression and area under the curve (AUC) analysis. The association between serum sodium levels (per 1 mEq/l increase) and the number of days with hypernatremia was also compa

SUBMITTER: Zaragoza JJ 

PROVIDER: S-EPMC12086689 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature