A triterpene-enriched natural extract from <i>Eucalyptus tereticornis</i> modulates the expression of genes involved in adipogenesis, lipolysis, and extracellular matrix remodeling in a primary human and mouse cell line adipocyte.

ABSTRACT:

Context

Obesity induces alterations in adipocyte size, tissue inflammation, vascularization, and extracellular matrix composition. Previous studies have shown that a leaf extract of Eucalyptus tereticornis Sm. (Myrtaceae), with ursolic acid, oleanolic acid, and ursolic acid lactone mixed with minor metabolites, provided a superior antiobesity effect than reconstituted triterpenoid mixtures in adipocyte cell lines and a pre-diabetic mouse model. Further identification of the molecular mechanisms of action of this mixture of triterpenes is required.

Objective

This study analyzes the effect of the natural extract and its components on early RNA expression profiles in human primary cultured adipocytes and a mouse cell line.

Materials and methods

RNA was sequenced u

SUBMITTER: Acin S 

PROVIDER: S-EPMC12086905 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature