Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation.

ABSTRACT:

Background

The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of ginsenoside Rg1, an active component of ginseng, on renal aging and injury.

Materials and methods

The potential targets of ginsenoside Rg1 in relieving renal aging and injury were predicted using network pharmacology. d-Galactose (d-gal) was used to induce aging and mice were randomly divided into six groups: a wild-type control group, a wild-type d-gal group, and a wild-type d-gal with Rg1 group (20 mg/kg/d), a caspase-1^-/- control group, a caspase-1^-/- d-gal group, and a caspase-1^-/- d-gal

SUBMITTER: Guo T 

PROVIDER: S-EPMC12086920 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature