CD28 and CTLA4 polymorphisms associated with ankylosing spondylitis: a study in the context of HLA-B27.

ABSTRACT:

Background

The human leukocyte antigen (HLA)-B27 gene is highly associated with ankylosing spondylitis (AS). However, not everyone who carries the HLA-B27 antigen develops AS, indicating that factors beyond the HLA-B27 gene contribute to the disease's onset. AS is an autoimmune disease in which co-stimulatory systems have been widely explored. Therefore, we aimed to analyze the association between single-nucleotide polymorphisms (SNPs) in co-stimulatory/inhibitory molecules and AS to identify other key factors involved in developing the disease.

Results

This study recruited 32 patients with AS and 32 controls. DNA was extracted from whole blood, and PCR amplification was performed to target the promoter regions of the CTLA4, CD28, and PDCD1 genes. Chi-square and Fisher's exa

SUBMITTER: Yu KH 

PROVIDER: S-EPMC12087045 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature