Identification and verification of a polyamine metabolism-related gene signature for predicting prognosis and immune infiltration in osteosarcoma.

ABSTRACT:

Background

Although an established correlation exists between tumor cell proliferation and elevated polyamine levels, research on polyamine metabolism in osteosarcoma (OS) remains limited. This study aimed to identify polyamine metabolism-related genes (PMRGs) associated with OS prognosis and develop a prognostic model, thereby offering novel insights into targeted therapies for patients with OS.

Methods

Datasets related to OS and PMRGs were sourced from publicly accessible databases. Candidate genes were initially identified through differential expression and weighted gene co-expression network analyses. Subsequently, prognostic genes were screened using univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analyses, leading to the developme

SUBMITTER: Qiu S 

PROVIDER: S-EPMC12087067 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature