M6Allele: a toolkit for detection of allele-specific RNA N6-methyladenosine modifications.

ABSTRACT:

Background

Allelic gene-specific regulatory events are crucial mechanisms in organisms, pivotal to many fundamental biological processes such as embryonic development and chromosome inactivation. Allelic gene imbalance manifests at both RNA expression and epigenetic levels. Recent research has unveiled allelic-specific regulation of RNA N6-methyladenosine (m6A), emphasizing the need for its precise identification. However, prevailing approaches primarily focus on screening allele-specific genetic variations associated with m6A, but not truly identify allelic m6A events. Therefore, the construction of a novel algorithm dedicated to identifying allele-specific m6A (ASm6A) signals is still necessary for comprehensively understanding the regulatory mechanism of ASm6A.

Findings

T

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12087454 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature