Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study.

ABSTRACT:

Objectives

We examined relationships between apathy (self and study-partner-reported) and markers of Alzheimer's disease (AD) in older adults.

Design

The study utilized a well-characterized sample of participants from the Harvard Aging Brain Study (HABS), a longitudinal cohort study. Participants were cognitively unimpaired without clinically significant neuropsychiatric symptoms at HABS baseline. The dependent variables, apathy evaluation scale-self (AES-S) and informant (AES-I), were administered cross-sectionally between years 6-9 and compared to the independent variables, amyloid and tau PET neuroimaging, from the same year.

Setting

Community-dwelling participants assessed at research visits in an academic medical center.

Participants

Participants (n = 170)

SUBMITTER: Burling JE 

PROVIDER: S-EPMC12087576 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature