Optimizing Brentuximab Vedotin Dosing in Pediatric Patients with Advanced Hodgkin Lymphoma: A Population Pharmacokinetic and Exposure-Response Analysis.

ABSTRACT: Pediatric patients with advanced-stage newly diagnosed Hodgkin lymphoma (HL) were treated with brentuximab vedotin (BV) combined with adriamycin, vinblastine, and dacarbazine (A + AVD). Weight-based BV dosing is employed in adult patients, while both body weight- and body surface area (BSA)-based dosing are used in pediatric patients. Data from two pediatric studies were used for a population pharmacokinetics (PK) analysis. Study 1 was a phase I/II dose-escalation study in which patients with relapsed or refractory systemic anaplastic large-cell lymphoma or HL received single-agent weight-based BV 1.4-1.8 mg/kg every 3 weeks. Study 2 tested BSA-based BV 48 mg/m² every 2 weeks with AVD in patients with advanced-stage, newly diagnosed HL. Sources of PK variability were quantified

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12087681 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature