Safety and efficacy of antigen-specific therapeutic approaches for multiple sclerosis: Systematic review.

ABSTRACT:

Introduction

The objective of this systematic review is to evaluate the efficacy and safety of antigen-specific tolerance-inducing therapeutic approaches (products based on peptides, DNA and T cells) versus placebo or other comparators, where possible, in adult multiple sclerosis (MS) patients.

Methods

PubMed, CINAHL, Web of Science, Cochrane and International Clinical Trials Registry Platform, ClinicalTrials.gov were searched for published and unpublished studies. Screening, critical appraisal, and data extraction for included studies were carried out by two independent reviewers. For efficacy, phase I, II and III clinical trials (randomized/non-randomized; double blind/single blind/unblinded; single-center/multicenter; single-arm/two-arm) and for safety, phase I, II and II

SUBMITTER: Ozturk HK 

PROVIDER: S-EPMC12088042 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature