NF-κB-mediated developmental delay extends lifespan in <i>Drosophila</i>.

ABSTRACT: Developmental time (or time to maturity) strongly correlates with an animal's maximum lifespan, with late-maturing individuals often living longer. However, the genetic mechanisms underlying this phenomenon remain largely unknown. This may be because most previously identified longevity genes regulate growth rate rather than developmental time. To address this gap, we genetically manipulated prothoracicotropic hormone (PTTH), the primary regulator of developmental timing in Drosophila, to explore the genetic link between developmental time and longevity. Loss of PTTH delays developmental timing without altering the growth rate. Intriguingly, PTTH mutants exhibit extended lifespan despite their larger body size. This lifespan extension depends on ecdysone signaling, as

SUBMITTER: Kang P 

PROVIDER: S-EPMC12088391 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature