Inhibitory circuit motifs in Drosophila larvae generate motor program diversity and variability.

ABSTRACT: How do neural networks generate and regulate diversity and variability in motor outputs with finite cellular components? Here we examine this problem by exploring the role that inhibitory neuron motifs play in generating mixtures of motor programs in the segmentally organised Drosophila larval locomotor system. We developed a computational model that is constrained by experimental calcium imaging data. The model comprises single-compartment cells with a single voltage-gated calcium current, which are interconnected by graded excitatory and inhibitory synapses. Local excitatory and inhibitory neurons form conditional oscillators in each hemisegment. Surrounding architecture reflects key aspects of inter- and intrasegmental connectivity motifs identified in the literature. The model generate

SUBMITTER: Francis J 

PROVIDER: S-EPMC12088524 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature