Genomic multiple sequence alignments: refinement using a genetic algorithm.

ABSTRACT:

Background

Genomic sequence data cannot be fully appreciated in isolation. Comparative genomics--the practice of comparing genomic sequences from different species--plays an increasingly important role in understanding the genotypic differences between species that result in phenotypic differences as well as in revealing patterns of evolutionary relationships. One of the major challenges in comparative genomics is producing a high-quality alignment between two or more related genomic sequences. In recent years, a number of tools have been developed for aligning large genomic sequences. Most utilize heuristic strategies to identify a series of strong sequence similarities, which are then used as anchors to align the regions between the anchor points. The resulting alignment is globa

SUBMITTER: Wang C 

PROVIDER: S-EPMC1208854 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature