Modern classification of neoplasms: reconciling differences between morphologic and molecular approaches.

ABSTRACT:

Background

For over 150 years, pathologists have relied on histomorphology to classify and diagnose neoplasms. Their success has been stunning, permitting the accurate diagnosis of thousands of different types of neoplasms using only a microscope and a trained eye. In the past two decades, cancer genomics has challenged the supremacy of histomorphology by identifying genetic alterations shared by morphologically diverse tumors and by finding genetic features that distinguish subgroups of morphologically homogeneous tumors.

Discussion

The Developmental Lineage Classification and Taxonomy of Neoplasms groups neoplasms by their embryologic origin. The putative value of this classification is based on the expectation that tumors of a common developmental lineage will share commo

SUBMITTER: Berman J 

PROVIDER: S-EPMC1208861 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature