Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology.

ABSTRACT:

Background

Quantitative differences between individuals stem from a combination of genetic and environmental factors, with the heritable variation being shaped by evolutionary forces. Drosophila wing shape has emerged as an attractive system for genetic dissection of multi-dimensional traits. We utilize several experimental genetic methods to validation of the contribution of several polymorphisms in the Epidermal growth factor receptor (Egfr) gene to wing shape and size, that were previously mapped in populations of Drosophila melanogaster from North Carolina (NC) and California (CA). This re-evaluation utilized different genetic testcrosses to generate heterozygous individuals with a variety of genetic backgrounds as well as sampling of new alleles from Kenyan stocks.

Results<

SUBMITTER: Palsson A 

PROVIDER: S-EPMC1208880 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature