Coinheritance of polymorphic alleles of <i>PIEZO1</i>, <i>G6PD</i> and <i>HBB</i> enhances protection against malaria.

ABSTRACT: Malaria has exerted potent selective pressure on the human genome over millennia and has been a significant force in shaping human evolution. We have determined in 424 individuals living in malaria-hyperendemic areas in Ghana and in the Democratic Republic of Congo, the genotypes at the loci PIEZO1, G6PD, HBB, and PKLR. By qPCR we have also estimated P. falciparum parasitemia in all these subjects. We found that 41% of individuals tested had one protective variant, 20.5% two variants, 6.4% three variants, and 0.7% four variants. We have confirmed that Pz_E756del, G6pd A-, and HbS are associated with lower parasite density. The highest allele frequency was that of Pz_E756del, approaching 0.2, and we found that it is in linkage d

SUBMITTER: Abad P 

PROVIDER: S-EPMC12088815 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature