Design, synthesis, and biological investigation of new thiazole-based derivatives as multi-targeted inhibitors endowed with antiproliferative, antioxidant, and antibacterial properties.

ABSTRACT:

Introduction

A novel series of thiazole-based derivatives 11a-f and 12a-f was developed, synthesized, and tested for antiproliferative activity as dual EGFR/VEGFR-2 inhibitors, antioxidants, and antibacterial agents.

Methods

The structures of the new compounds 11a-f and 12a-f were validated using NMR spectroscopy and elemental microanalysis. The antiproliferative activity of 11a-f and 12a-f was tested against a panel of four cancer cell lines using MTT assay.

Results and discussion

Compounds 11d and 11f had the highest antiproliferative activity, with GI₅₀ values of 30 and 27 nM, respectively, making them more potent than erlotinib (GI₅₀ = 33 nM). Inhibitory studies for EGFR and VEGFR-2 demo

SUBMITTER: Gomaa HAM 

PROVIDER: S-EPMC12088962 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature