Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using <i>in silico</i> techniques.

ABSTRACT:

Introduction

Male pattern hair loss (MPHL), also known as androgenetic alopecia (AGA), is a common disorder primarily caused by dihydrotestosterone (DHT). The Food and Drug Administration (FDA) has approved two 5-alpha reductase (5-AR) inhibitors-finasteride and dutasteride-for treating this condition. However, recent studies have reported adverse sexual side effects and issues with sperm production in young men using these medications. There are also recommendations for effectively treating hair loss with natural remedies, such as Urtica dioica (nettle), Serenoa repens (saw palmetto), and Trigonella foenum-graecum (fenugreek) that is mainly used for diminish the hair loss in the traditional medicine. Research shows that these herbal formulations and plant extr

SUBMITTER: Hasannejad-Asl B 

PROVIDER: S-EPMC12089051 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature