Impaired K48-polyubiquitination downmodulates mouse norovirus propagation.

ABSTRACT:

Introduction

Noroviruses are small non-enveloped, single stranded positive-sense RNA viruses that belong to the family Caliciviridae. They are highly contagious and resistant to multiple detergents and are the infectious agents in the majority of viral gastroenteritis in adults. Due to a lack of approved preventive or curative therapy options, intensive research effort is ongoing to better understand the pathogenesis mechanisms of noroviruses.

Methods

In this study, using the persistent murine norovirus S99 strain (MNoV_S99), we have investigated the role in the regulation of anti-noroviral responses of ubiquitination, a post-translational modification that covalently adds one or multiple ubiquitin molecules onto lysine residues of target proteins. To that end, we hav

SUBMITTER: Wakeford E 

PROVIDER: S-EPMC12089143 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature