Osteoporosis and stroke: a bidirectional mendelian randomization study.

ABSTRACT:

Introduction

Numerous observational studies have identified a link between osteoporosis and stroke. However, the causal genetic relationship between these conditions remains unclear. This study employs a two-sample bidirectional Mendelian randomization (MR) approach to ascertain the causal relationship between osteoporosis and stroke.

Materials and methods

We conducted a two-sample Mendelian randomization (MR) study to investigate the potential causal relationship between osteoporosis and stroke, including its subtypes. Genetic data for osteoporosis and stroke, along with their subtypes, were sourced from published genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) demonstrating genome-wide significance (p < 5 × 10^ - 8) and independence (r^2 < 0.

SUBMITTER: He M 

PROVIDER: S-EPMC12089162 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature