Incidence of opioid-induced constipation in non-cancer patients using weak opioids for chronic pain in Japan: a cohort study.

ABSTRACT: Opioid-induced constipation (OIC) is a common adverse drug reaction of opioids. However, limited evidence exists regarding the incidence of OIC, as diagnosed using the Rome IV criteria, in non-cancer patients newly prescribed weak opioids for chronic pain in Japan. This study aimed to clarify the incidence of OIC in patients aged ≥ 18 years who were newly prescribed weak opioids in outpatient settings in Japan. This study was conducted from February 1, 2023, to July 13, 2024 (trial registration number: UMIN000050203), using a patient-reported, web-based questionnaire survey. Of the 64 participants (mean age: 53.2 years) included, 63 participants received weak opioids for ≥ 7 days. The cumulative incidence of OIC (95% confidence interval) was 30.2% (20.4-43.1) in the first week and increase

SUBMITTER: Hashimoto A 

PROVIDER: S-EPMC12089302 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature