Biocompatibility of a novel lung sealant based on functionalized polyoxazolines in an ovine model of parenchymal lung injury.

ABSTRACT:

Background

A lung sealant based on a porcine gelatin carrier impregnated with N-hydroxysuccinimide ester functionalized poly(2)oxazolines (NHS-POx) and nucleophilically activated polyoxazolines (NU-POx) was shown to be efficacious for lung sealing ex-vivo and in-vivo. In the current study, we investigated the local biocompatibility by assessing inflammation, healing, and biodegradability in an ovine model of superficial parenchymal lung injury.

Methods

Three groups, NHS-POx, fibrin patch (TachoSil^®) and untreated control, are randomly applied to superficial lesions (3 mm depth) on the right lung (n=3/lung) of adult female domestic sheep, which are sacrificed for blinded histological assessment at 5, 14, and 42 days (n=4 animals per term). Semi-quanti

SUBMITTER: Hermans BP 

PROVIDER: S-EPMC12090121 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature