Prenatal exposure to phthalates and phthalate replacements in relation to chorionic plate surface vasculature at delivery.

ABSTRACT: Pregnant people are ubiquitously exposed to endocrine-disrupting phthalates through consumer products and food. The placenta may be particularly vulnerable to the adverse effects of phthalates, with evidence from animal models suggesting impacts on placental development and vascularization. We translate this research to humans, examining gestational exposure to phthalates and phthalate replacements in relation to novel markers of chorionic plate surface vascularization. Phthalate and phthalate replacement metabolites were measured in first trimester urine from pregnant participants in the Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort (n = 154). At delivery, placentae underwent specialized 2D and 3D digital imaging to quantify chorionic plate surface vasculature. Us

SUBMITTER: Barrett ES 

PROVIDER: S-EPMC12090374 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature