FGA can be used as a promising therapeutic target in osteoarthritis.

ABSTRACT:

Background

This study aims to identify critical signaling pathways and pathogenic genes involved in osteoarthritis (OA) to provide a foundation for identifying targeted therapeutic strategies.

Methods

Twenty-six patients who underwent knee joint surgery in the Department of Orthopedics between January and December 2023 were enrolled. Cartilage samples in the experimental group (OA group) were harvested from the articular surfaces of the knee joints of OA patients undergoing total knee arthroplasty (TKA). In contrast, control samples were obtained from non-load-bearing regions of irreparable cartilage fragments excised during surgical management of tibial plateau fractures. Proteomic profiling was conducted using label-free quantitative mass spectrometry-based proteomics. Sub

SUBMITTER: Chen G 

PROVIDER: S-EPMC12090478 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature