Statins for primary prevention of cardiovascular events in people with HIV: target trial and modelling study.

ABSTRACT:

Objective

To evaluate the effectiveness and benefit-harm balance of various statins for the primary prevention of cardiovascular disease in people with HIV.

Design

Target trial and modelling study.

Setting

North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), 1995 to 2019. NA-ACCORD integrates individual level data from >20 HIV cohorts across the US and Canada from people with HIV who have successfully linked into care.

Participants

157 699 people with HIV enrolled in one of the cohorts of NA-ACCORD. 54 165 eligible individuals, aged 40-75 years, were enrolled in the target trial.

Main outcome measures

The primary outcomes for the target trial were the 10 year effects of statins on cardiovascular disease events (fatal and non-fatal

SUBMITTER: Yebyo HG 

PROVIDER: S-EPMC12090529 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature