Molecular characteristics of the immune escape of coronavirus PEDV under the pressure of vaccine immunity.

ABSTRACT: Coronaviruses have undergone evolutionary changes and mutations in response to the immune pressures exerted by vaccines and environmental factors, resulting in more severe consequences during breakthrough infections. Nevertheless, the specific correlation between the evolutionary mutations of coronaviruses and immune pressures remains ambiguous. Swine coronavirus-porcine epidemic diarrhea virus (PEDV)-has existed for decades. This study utilized in vivo preparation of polyclonal antibodies against the PEDV and identified critical neutralizing epitopes through serial in vitro passaging. Then, the recombinant mutated strains were successfully constructed. In vitro experiments confirmed the ability of the rA1273P strain to escape neutralization by polyclonal antibodies. B

SUBMITTER: Li Y 

PROVIDER: S-EPMC12090811 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature