Differential genome organization revealed by comparative topological analysis of <i>Mycobacterium tuberculosis</i> strains H37Rv and H37Ra.

ABSTRACT: Recent studies have shown that three-dimensional architecture of bacterial chromatin plays an important role in gene expression regulation. However, genome topological organization in Mycobacterium tuberculosis, the etiologic agent of tuberculosis, remains unknown. On the other hand, the exact mechanism of differential pathogenesis in the canonical strains of M. tuberculosis H37Rv and H37Ra remains poorly understood in terms of their raw sequences. In this context, a detailed contact map from a Hi-C experiment is a candidate for what bridges the gap. Here, we present the first comprehensive report on genome-wide contact maps between regions of H37Rv and H37Ra genomes. We tracked differences between the genome architectures of H37Rv and H37Ra, which could possibly explain the

SUBMITTER: Mishra M 

PROVIDER: S-EPMC12090813 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature