Mitigation of PFAS toxicity through sorbent treatment in Sprague-Dawley rats during prenatal and postnatal exposure.

ABSTRACT: PFAS (per- and polyfluoroalkyl substances) are prevalent and persistent environmental pollutants with significant toxicity, especially during critical windows of exposure such as pregnancy and lactation. This study investigated the prenatal and postnatal effects of PFAS exposure on the serum and liver of Sprague-Dawley rats, and the mitigating efficacy of orally administered sorbents. Animal groups included vehicle control, PFAS (0.95 mg/kg-bw/day), and PFAS co-treated with calcium montmorillonite (CM), CM-carnitine, CM-choline, activated carbon (AC), or acid processed montmorillonite (APM). Oral administration of PFAS resulted in accumulation in serum and liver by postnatal day (PND) 21, especially for PFOS. PFAS exposure also reduced body weight gain by 24 % in females and 35 % in males

SUBMITTER: Wang M 

PROVIDER: S-EPMC12090993 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature