A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity.

ABSTRACT: The conserved Spalt proteins regulate gene expression and cell fate choices during multicellular development, generally acting as transcriptional repressors in different gene regulatory networks. In addition to their roles as DNA sequence-specific transcription factors, Spalt proteins show a consistent localization to heterochromatic regions. Vertebrate Spalt-like proteins can act through the nucleosome remodeling and deacetylase complex to promote closing of open chromatin domains, but their activities also rely on interactions with DNA methyltransferases or with the lysine-specific histone demethylase LSD1, suggesting that they participate in multiple regulatory mechanisms. Here, we describe several consequences of loss of Spalt function in Drosophila cells, including changes in chromati

SUBMITTER: Ostale CM 

PROVIDER: S-EPMC12091872 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature