Alterations of the gut commensal <i>Akkermansia muciniphila</i> in patients with COVID-19.

ABSTRACT: Dysbiosis of gut microbiota is well established in coronavirus disease 2019 (COVID-19). While studies have attempted to establish a link between the gut commensal Akkermansia muciniphila (A. muciniphila) and COVID-19, the findings have been inconsistent and sometimes controversial. The intestinal microbial abundance information of COVID-19 patients was acquired and analysed from GMrepo database. Subsequently, A. muciniphila's metabolites, target-genes, and metabolite-target relationships was extracted from GutMGene database. Lastly, coronascape module in Metascape database is used for gene annotation and enrichment analysis in various host cells and tissues after SARS-CoV-2 infection. The results indicated that, in comparison to healthy people, A. muciniphila wa

SUBMITTER: Dai ZM 

PROVIDER: S-EPMC12091934 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature