Disruption of macroscale functional network organisation in patients with frontotemporal dementia.

ABSTRACT: Neurodegenerative dementias have a profound impact on higher-order cognitive and behavioural functions. Investigating macroscale functional networks through cortical gradients provides valuable insights into the neurodegenerative dementia process and overall brain function. This approach allows for the exploration of unimodal-multimodal differentiation and the intricate interplay between functional brain networks. We applied cortical gradients mapping to resting-state functional MRI data of patients with frontotemporal dementia (FTD) (behavioural-bvFTD, non-fluent and semantic) and healthy controls. In healthy controls, the principal gradient maximally distinguished sensorimotor from default-mode network (DMN) and the secondary gradient visual from salience network (SN). In all FTD variant

SUBMITTER: Bouzigues A 

PROVIDER: S-EPMC12092252 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature