Choroid plexus free-water correlates with glymphatic function in Alzheimer's disease.

ABSTRACT:

Introduction

Free-water imaging of the choroid plexus (CP) may improve the evaluation of Alzheimer's disease (AD).

Methods

Our study investigated the role of free-water fraction (FWf) of CP in AD among 216 participants (133 Aβ+ participants and 83 Aβ- controls) enrolled in the NeuroBank-Dementia cohort at Ruijin Hospital (RJNB-D). The Alzheimer's Disease Neuroimaging Initiative dataset was used for external validation.

Results

At baseline, Aβ+ participants showed higher CP FWf, increased white matter hyperintensity (WMH) volume, and decreased diffusion tensor image analysis along the perivascular space (DTI-ALPS). In Aβ+ participants, DTI-ALPS mediated the association between CP FWf and periventricular WMH. CP FWf was associated with cortical tau accumulation, synapti

SUBMITTER: Xu X 

PROVIDER: S-EPMC12092370 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature