Phage (cocktail)-antibiotic synergism: a new frontier in addressing <i>Klebsiella pneumoniae</i> resistance.

ABSTRACT: Phages, which play a crucial role in regulating bacterial populations and evolution, have gained renewed attention as potential therapeutic agents especially in the face of rising antimicrobial resistance, such as in Klebsiella pneumoniae- a MDR pathogen with significant clinical implications for immunocompromised individuals. In this milieu, the present investigation aimed at evaluating the therapeutic potential of two lytic phages, KPKp (jumbo phage) and KSKp, as potential candidates for phage treatment. Initial purification and TEM characterization revealed their family as Ackermannviridae (KPKp) and Straboviridae (KSKp). The one-step growth curve analysis divulged that KPKp and KSKp exhibit burst sizes of ~98 and ~121 and latency periods of 8 and 12 min, respective

SUBMITTER: Karthika C 

PROVIDER: S-EPMC12092377 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature