Topological data analysis captures horizontal gene transfer in antimicrobial resistance gene families among clinically relevant bacteria.

ABSTRACT: Antibiotic resistance, projected to cause 10 million deaths annually by 2050, remains a critical health threat. Hospitals drive multidrug resistance via horizontal gene transfer. The 2023 Critical Assessment of Massive Data Analysis challenge presents resistance markers from 146 Johns Hopkins bacterial isolates, aiming to analyze resistomes without metadata or genomic sequences. Persistent homology, a topological data analysis method, effectively captures processes beyond vertical inheritance. A 1-hole is a topological feature representing a loop or gap in the data, where relationships form a circular structure rather than a linear one. Unlike vertical inheritance, which lacks topological 1-holes, horizontal gene transfer generates distinct patterns. Since antimicrobial resistance genes of

SUBMITTER: Guerrero-Flores S 

PROVIDER: S-EPMC12092391 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature