Isolation and validation of antimalarial compounds from Phyllanthus emblica leaves for new antimalarial drug development.

ABSTRACT: Natural products can serve as an alternative source of novel therapies that are required to address the problem of malarial infection resistance. Indian gooseberry (Phyllanthus emblica L.) leaves are often used in traditional medicine to treat fevers, but there isn't enough scientific proof that they contain antimalarial and effective phytochemicals. This study's primary goal was to investigate the antimalarial efficacy of P. emblica leaf ethyl acetate extract against Plasmodium falciparum (3D7) and its cytotoxicity against the HeLa cell line. The active compounds from P. emblica were isolated using a bioassay-guided fractionation of column chromatography technique, and NMR spectroscopy was employed to identify their structures. The drug's anti-malarial efficacy was assessed by estimating

SUBMITTER: Naveenkumar S 

PROVIDER: S-EPMC12092577 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature