Mendelian randomization analysis reveals the causal relationship between immune cells and leukemia.

ABSTRACT:

Background

Increasing evidence indicates certain types of immune cells are linked to leukemia, but whether this link is causal has remained unclear.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted to examine the causal relationship (CR) among 731 immune cell traits and leukemia. The inverse variance weighted (IVW) technique was applied, along with the weighted median and MR-Egger approaches, to analyze the data. The instrumental variables were validated for heterogeneity and pleiotropy using sensitivity analyses.

Results

A total of 58 immune cell traits with CRs with leukemia were identified, of which 15 were considered risk factors for leukemia. The factors were distributed among acute myeloid leukemia (AML) (3 traits), acute lymphoblastic le

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12092886 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature