An open-source SQL database schema for integrated clinical and translational data management in clinical trials.

ABSTRACT: Unlocking the power of personalised medicine in oncology hinges on the integration of clinical trial data with translational data (i.e. biospecimen-derived molecular information). This combined analysis allows researchers to tailor treatments to a patient's unique biological makeup. However, current practices within UK Clinical Trials Units present challenges. While clinical data are held in standardised formats, translational data are complex, diverse, and requires specialised storage. This disparity in format creates significant hurdles for researchers aiming to curate, integrate and analyse these datasets effectively. This article proposes a novel solution: an open-source SQL database schema designed specifically for the needs of academic trial units. Inspired by Cancer Research UK's co

SUBMITTER: Niazi U 

PROVIDER: S-EPMC12092935 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature