αB-crystallin enhances radioresistance in basal-like breast cancer cells by suppressing caspase-3 activation.

ABSTRACT: ObjectiveFor most patients with breast cancer undergoing breast-conserving surgery, radiotherapy reduces local recurrence and mortality. However, in basal-like breast cancer, radiotherapy is less effective due to the cells' intrinsic radioresistance. Understanding the molecular mechanism of radioresistance in basal-like breast cancer is crucial for improving treatment and outcomes.MethodsαB-crystallin levels were determined in different breast cancer cell lines, including basal-like breast cancer cell lines (HCC1599, MDA-MB-468, MDA-MB-231) and luminal breast cancer cell lines (MDA-MB-453, BT-474, MCF-7). To further investigate the role of αB-crystallin in breast cancer cells, we utilized short hairpin RNA lentivirus particles to knock down αB-crystallin expression in MDA-MB-231 cells and

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC12092982 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature