Quantum-inspired logic for advanced Transcriptional Programming.

ABSTRACT: The tenets of intelligent biological systems are (i) scalable decision-making, (ii) inheritable memory, and (iii) communication. This study aims to increase the complexity of decision-making operations beyond standard Boolean logic, while minimizing the metabolic burden imposed on the chassis cell. To this end, we present a new platform technology for constructing genetic circuits with multiple OUTPUT gene control using fewer INPUTs relative to conventional genetic circuits. Inspired by principles from quantum computing, we engineered synthetic bidirectional promoters, regulated by synthetic transcription factors, to construct 1-INPUT, 2-OUTPUT logical operations-i.e. biological QUBIT and PAULI-X logic gates-designed as compressed genetic circuits. We then layered said gates to engineer ad

SUBMITTER: Milner PT 

PROVIDER: S-EPMC12093148 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature