Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation.

ABSTRACT: The metalloprotease meprin β is known for its multifunctional involvement in various physiological processes throughout the body including the brain. However, its broader functions within the brain besides amyloid β generation remain largely unexplored. To investigate this, we utilized a mouse model overexpressing meprin β in neurons within the cortex and hippocampus, regions crucial for learning and memory. Behavioral assessments, employing the Morris' Water Maze paradigm test, revealed impaired cognitive functions in animals overexpressing meprin β. Furthermore, electrophysiological recordings in hippocampal slices using multielectrode arrays showed an impaired long-term potentiation (LTP) in meprin β-overexpressing mice compared to wild-type counterparts. Intriguingly, concomitant with

SUBMITTER: Keller M 

PROVIDER: S-EPMC12093287 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature