Universal Proteomic Signature After Exercise-Induced Muscle Injury in Muscular Dystrophies.

ABSTRACT:

Objective

Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity-related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins relative to unaffected individuals. While the interplay between the nature of the muscle injury and the specific genetic driver is poorly understood, the similarities exhibited by various NMDs suggest that a common proteomic signature of muscle injury may exist.

Methods

We used an established exercise challenge and the SOMAscan proteomics platform to study the baseline and post-exercise proteomic profiles in a cross-sectional study of thre

SUBMITTER: Stemmerik MG 

PROVIDER: S-EPMC12093346 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature