<i>Batf3</i>-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation.

ABSTRACT: The BATF3-dependent cDC1 lineage of conventional dendritic cells (cDC) is required for rejection of immunogenic sarcomas and for rejection of progressive sarcomas during checkpoint blockade therapy. One unique function of the cDC1 lineage is the efficient cross-presentation of tumor-derived neoantigens to CD8⁺ T cells, but it is not clear that this is the only unique function of cDC1 required for tumor rejection. We previously showed that BATF3 functions during cDC1 lineage commitment to maintain IRF8 expression in the specified cDC1 progenitor. However, since cDC1 progenitors do not develop into mature cDC1s in Batf3 ^-/- mice, it is still unclear whether BATF3 has additional functions in mature cDC1 cells. A transgenic Irf8-Venus reporter allele increas

SUBMITTER: Theisen DJ 

PROVIDER: S-EPMC12093468 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature