Identification and characterization of a novel human adenovirus type HAdV-D116.

ABSTRACT:

Introduction

Human adenovirus infections are typically associated with acute respiratory infection, keratoconjunctivitis, acute cystitis, hepatitis, and gastroenteritis, while central nervous system (CNS) related infections are rarely reported.

Methods

In this study, a novel human adenovirus was identified in the cerebrospinal fluid from an encephalitis patient with X-linked agammaglobulinemia via metagenomic next-generation sequencing (mNGS). Probe capture enrichment sequencing and PCR validation further confirmed the presence of this adenovirus in the patient's cerebrospinal fluid.

Results

Whole-genome analysis classified the virus within the Human mastadenovirus D species, revealing an approximately 2000 bp deletion in the E3 gene that resulted in the loss of CR1-g

SUBMITTER: Zhou M 

PROVIDER: S-EPMC12093491 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature