Synthesis, characterization, and <i>in vitro</i> and <i>in silico</i> α-glucosidase inhibitory evolution of novel <i>N</i>'-(2-cyclopentyl-2-phenylacetyl)cinnamohydrazide derivatives.

ABSTRACT: To discover potential α-glucosidase inhibitory agents, a new series of N'-(2-cyclopentyl-2-phenylacetyl)cinnamohydrazide derivatives were designed and synthesized as α-glucosidase inhibitors. The newly synthesized compounds were characterized using ¹H, ¹³C NMR, and mass spectroscopy analysis and evaluated for their in vitro α-glucosidase inhibitory effects. All the tested compounds displayed significant α-glucosidase inhibitory activity compared to the standard drug acarbose. Among all, compounds 7b, 7d and 6g exhibited the strongest inhibition with IC₅₀ values of 14.48 nmol, 18.88 nmol and 28.51 nmol, respectively. Molecular docking analysis was conducted to identify the important binding interactions responsible for inhibition activity of a-

SUBMITTER: Mudireddy RR 

PROVIDER: S-EPMC12093506 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature