Adaptation mechanisms of Brucella abortus to low magnesium ion stress.

ABSTRACT:

Background

Brucella abortus, a facultative intracellular pathogenic bacterium that usually causes diseases under animals and humans, can survive and replicate within phagocytic cells. Within the host cells, B. abortus has to adapt to low cytosolic magnesium ion (Mg²⁺) environment, which is critical for bacterial survival and replication. To understand the fitness of B. abortus under the low Mg²⁺ environment, transcriptome analysis was performed by RNA-seq. Results: 262 differentially expressed genes (DEGs, fold-change > 1.5 and p < 0.05) of B. abortus, 123 significantly upregulated genes and 139 significantly downregulated genes, were identified under Mg²⁺ starvation environment, highlighting that B. abortus probably employed large amounts of factor

SUBMITTER: Wang H 

PROVIDER: S-EPMC12093621 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature