Potential drug targets for peripheral artery disease identified through Mendelian randomization analysis.

ABSTRACT:

Introduction

Peripheral Artery Disease (PAD) is a common cardiovascular condition marked by peripheral artery stenosis or occlusion. Despite treatment advancements, patients will still face vascular complications, highlighting the need for innovative therapies. Human proteins play crucial roles in biology and drug research. Mendelian randomization (MR) analysis, a gene-based method, is increasingly used in drug target identification. This study aims to identify PAD-associated plasma proteins through MR analysis for potential therapies.

Methods

We first used GWAS data and seven pQTL datasets to identify plasma proteins causally linked to PAD through MR analysis. Then, we performed KEGG pathway enrichment analysis, Bayesian colocalization analysis, and MR-BMA analysis were car

SUBMITTER: Ding X 

PROVIDER: S-EPMC12093625 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature