Chicken interferon-induced transmembrane proteins inhibit Newcastle disease virus infection by affecting viral entry and W protein expression.

ABSTRACT: Interferon-induced transmembrane proteins (IFITMs) are essential components of the innate immune system, demonstrating potent resistance to various enveloped viruses (such as influenza, West Nile, and dengue viruses) both in laboratory settings and in living organisms. Newcastle disease (ND), resulting from Newcastle disease virus (NDV), is a severe avian viral ailment with notable economic impact due to its significant mortality and morbidity rates. On the basis of the efficient antiviral effects of IFITMs, an in-depth study of the role and mechanism of NDV inhibition by chicken IFITMs (chIFITMs) is highly important for the prevention and control of this disease. In this study, we found that transient overexpression of chIFITMs effectively inhibited NDV (NDV Lasota, NDV Na) infection in D

SUBMITTER: Chen J 

PROVIDER: S-EPMC12093685 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature