The causal role of homocysteine in multiple diseases: a systematic review of Mendelian randomization studies.

ABSTRACT:

Background

Homocysteine (Hcy) has been implicated in the development of multiple diseases; however, its causal role remains unclear. Mendelian randomization (MR) studies provide a robust approach to assessing causality by minimizing confounding and reverse causation.

Objective

This study aimed to evaluate the causal role of Hcy in various diseases by synthesizing evidence from MR studies.

Methods

We performed a comprehensive literature search in PubMed, the Cochrane Library, Embase, and Web of Science for MR studies published up to May 30, 2024. Studies investigating the association between genetic predisposition to Hcy levels and specific diseases were included.

Results

Findings from 33 MR studies (covering 31 distinct primary outcomes) suggest that geneticall

SUBMITTER: Zhu X 

PROVIDER: S-EPMC12093736 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature