Identification of key genes and metabolites involved in intramuscular fat deposition in Laiwu pigs through combined transcriptomic and lipidomic analyses.

ABSTRACT: Pork quality is a key goal in commercial pig farming. Intramuscular fat (IMF) content in pigs serves as a critical determinant of meat quality, yet its regulatory mechanism remains unclear. In this study, two different pig breeds Chinese native breed Laiwu (fatty-type) and Yorkshire (lean-type), were selected as research subjects. The molecular regulatory mechanisms affecting IMF content were investigated through integrated transcriptomic and lipidomic analysis. We identified critical genes, including ACC1, FASN, ELOVL6, SCD, and DGAT2, and elucidated their synergistic interactions in promoting IMF deposition in Laiwu pigs. The findings reveal that the coordinated action of genes such as ACC1 and FASN promotes the increased production of palmitic acid, which was subsequently elongated and

SUBMITTER: Peng WC 

PROVIDER: S-EPMC12093822 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature